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Yeast Fitness
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YLL019C / KNS1



Section 1: Phenotypes.
Gene-drug relationships for YLL019C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLL019C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for KNS1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 500 uM 11.803 < 1e-12
k2cr2o7 6.25 uM 6.83151 5.0054e-08
itraconazole 17.7 uM 5.8657 2.1478e-07
dyclonine 500 uM 5.73849 4.6652e-05
norcantharidin 2500 uM 4.76738 1.9513e-05
econazole nitrate 0.24 uM 4.56319 1.8105e-05
methotrexate 250 uM 4.48326 4.4293e-05
acriflavinium hydrochloride 250 uM 4.42441 2.8547e-05
itraconazole 4.4 uM 3.84369 0.00018148
terbinafine 7.2 uM 3.73677 0.0014193

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for KNS1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fk506 0.1 ug/ml 12.4121 < 1e-12
fk506 0.05 ug/ml 10.9161 < 1e-12
nacl 1000 uM 10.2656 6.2469e-07
nacl 1000 uM 9.70798 1.0421e-06
nacl 600 mM 9.38926 2.8558e-11
methoxsalen 500 uM 7.88326 1.1639e-08
methoxsalen 500 uM 7.87753 1.1797e-08
phosphatase inhibitor 3 uM 7.71315 2.8537e-09
sorbitol 1.5 M 7.4579 1.0826e-05
sorbitol 1 M 7.08414 1.7483e-08

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YLL019C

Top 10 functional gene interactors with YLL019C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with KNS1 by heterozygous co-sensitivity:

Query Interactor Correlation
KNS1 BEM3 0.38265
KNS1 ATG29 0.37682
KNS1 IME1 0.3622
KNS1 GDE1 0.3606
KNS1 VIP1 0.33781
KNS1 CPR2 0.33437
KNS1 SSE2 0.33378
KNS1 YDR020C 0.32642
KNS1 SHG1 0.32122
KNS1 CLN3 0.31943

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with KNS1 by homozygous co-sensitivity:

Query Interactor Correlation
KNS1 FMS1 0.78623
KNS1 AHT1 0.77271
KNS1 YPR014C 0.76619
KNS1 RNP1 0.76325
KNS1 DBP1 0.75825
KNS1 YER186C 0.73473
KNS1 YOL029C 0.73263
KNS1 GAS5 0.73107
KNS1 FSH1 0.72743
KNS1 YHR126C 0.72653

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YLL019C

Other databases:

Visit YLL019C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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