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Yeast Fitness

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YLL011W / SOF1

Section 1: Phenotypes.
Gene-drug relationships for YLL011W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YLL011W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SOF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 11.806 0.0035491
alverine citrate 500 uM 8.86116 0.0062487
lapachol 500 uM 8.5007 2.4653e-11
cantharidin analog 250 uM 8.01147 1.9028e-09
methotrexate 500 uM 7.6909 4.5549e-09
tryptanthrin 250 uM 6.07088 4.4213e-07
drofenine hydrochloride 750 uM 5.81848 2.5308e-07
fluconazole 130.6 uM 5.09494 3.0489e-06
metergoline 250 uM 5.05709 3.4668e-06
k2cr2o7 6.25 uM 4.1277 0.00012216

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YLL011W

Top 10 functional gene interactors with YLL011W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with SOF1 by heterozygous co-sensitivity:

Query Interactor Correlation
SOF1 RPA43 0.39191
SOF1 CCW14_p 0.37248
SOF1 POL2 0.36737
SOF1 VRP1 0.36575
SOF1 GPI13 0.35788
SOF1 RPL15A 0.35787
SOF1 PSF2 0.35767
SOF1 CDC9 0.35531
SOF1 TYS1 0.35148
SOF1 MPP10 0.34457

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YLL011W

Other databases:

Visit YLL011W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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