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Yeast Fitness
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YKR101W / SIR1



Section 1: Phenotypes.
Gene-drug relationships for YKR101W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR101W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SIR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 5.30495 0.016873
alverine citrate 500 uM 4.36493 0.024343
clotrimazole 1 uM 3.25931 0.0010398
protoveratrine b 10000 uM 2.94129 0.0025297
dyclonine 500 uM 2.93241 0.0062738
AG 1478 (Biomol) 100 uM 2.76997 0.0046274
tomatine 62.5 uM 2.69152 0.0049106
drofenine hydrochloride 750 uM 2.64853 0.0054863
telomerase inhibitor ix (Biomol) 500 uM 2.62503 0.0065873
hydroxyurea 100000 uM 2.5445 0.0071441

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SIR1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
allyl disulfide 0.06 % 9.12626 5.7452e-11
thiabendazole 250 uM 7.10147 7.6562e-08
l-dopa 12.5 ug/ml 6.36067 1.4704e-07
rapamycin 9 nM 5.13372 0.0071579
cadmium chloride 7.81 uM 4.2999 6.8002e-05
methotrexate 250 uM 4.17846 0.00014657
methotrexate 250 uM 4.15912 0.0001542
synthetic complete for BY4743 0 3.99506 0.01405
methotrexate 500 uM 3.65891 0.00089782
mycophenolic acid 125 uM 3.61739 0.00062868

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR101W

Top 10 functional gene interactors with YKR101W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SIR1 by heterozygous co-sensitivity:

Query Interactor Correlation
SIR1 YHR033W 0.54508
SIR1 COS10 0.5379
SIR1 MET10 0.51093
SIR1 YDL183C 0.49997
SIR1 YDR066C 0.49707
SIR1 YMR210W 0.48648
SIR1 HLR1 0.47326
SIR1 PST1 0.47316
SIR1 YJL016W 0.46985
SIR1 VMR1 0.4675

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SIR1 by homozygous co-sensitivity:

Query Interactor Correlation
SIR1 TEF4 0.50815
SIR1 FKS3 0.39526
SIR1 YDL241W 0.3839
SIR1 UBP7 0.38011
SIR1 NRK1 0.37567
SIR1 GND2 0.37246
SIR1 FMP45 0.37121
SIR1 COS10 0.36682
SIR1 YGR269W 0.36485
SIR1 YKR077W 0.35563

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YKR101W

Other databases:

Visit YKR101W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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