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YKR094C / RPL40B



Section 1: Phenotypes.
Gene-drug relationships for YKR094C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR094C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL40B Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fenpropimorph 0.4 nM 3.7101 0.00027359
paclitaxel 250 uM 2.74918 0.0048703
fenbendazole 500 uM 2.71836 0.00458
merbromin 62.5 uM 2.6448 0.005539
methotrexate 125 uM 2.3371 0.011873
leucovorin 500 uM 2.15816 0.018028
amoxepine 500 uM 2.06216 0.022372
bufexamac 1000 uM 1.9899 0.026219
clofoctol 1000 uM 1.91787 0.030607
nitromide 1000 uM 1.81533 0.037929

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPL40B Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cisplatin 125 uM 5.13221 1.1858e-05
cisplatin 66 uM 4.19865 0.00013901
cisplatin 125 uM 3.75758 0.00043847
cisplatin 62.5 uM 3.72272 0.00047969
clotrimazole 2 uM 3.69561 0.00051436
cisplatin 500 uM 3.55813 0.00073146
cisplatin 31.25 uM 3.45811 0.0009432
cisplatin 500 uM 3.28287 0.0014657
synthetic complete for BY4743 0 3.14734 0.0051899
cisplatin 125 uM 2.71511 0.0058065

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR094C

Top 10 functional gene interactors with YKR094C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPL40B by heterozygous co-sensitivity:

Query Interactor Correlation
RPL40B RPL12A 0.59846
RPL40B RPL19A 0.59576
RPL40B RPL19B 0.58661
RPL40B RPL43A 0.58069
RPL40B RPL5 0.57985
RPL40B RPL35B 0.5652
RPL40B RPL37A 0.5579
RPL40B RPL6A 0.55713
RPL40B RPL20B 0.55709
RPL40B YBR190W 0.55407

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

Top 10 interactors with RPL40B by homozygous co-sensitivity:

Query Interactor Correlation
RPL40B RPL24B 0.56458
RPL40B SNU66 0.54102
RPL40B YNR004W 0.51627
RPL40B TOS1 0.51456
RPL40B YDL063C 0.49148
RPL40B NOP12 0.49018
RPL40B YBR025C 0.48933
RPL40B YNL050C 0.47171
RPL40B RPL31B 0.47071
RPL40B YNL213C 0.46816

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YKR094C

Other databases:

Visit YKR094C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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