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Yeast Fitness
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YKR093W / PTR2



Section 1: Phenotypes.
Gene-drug relationships for YKR093W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR093W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PTR2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dyclonine 500 uM 6.90662 8.1784e-06
methotrexate 500 uM 6.4698 1.4027e-07
methotrexate 500 uM 5.85807 8.188e-07
methotrexate 500 uM 5.77463 1.0432e-06
itraconazole 4.4 uM 5.67269 4.1962e-07
fenpropimorph 4.7 uM 4.87293 6.4549e-06
bithionol 75 uM 4.73438 1.0263e-05
fenpropimorph 2.3 uM 4.65829 0.00027625
bithionol 75 uM 4.62544 1.4739e-05
dyclonine 500 uM 4.29659 0.00051906

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PTR2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 27.4391 0.00066277
miconazole 50 nM 21.754 < 1e-12
clotrimazole 2 uM 18.732 < 1e-12
latrunculin 0.78 uM 18.6241 0.00016894
miconazole 50 nM 18.3404 < 1e-12
lovastatin 154.5 uM 16.5984 < 1e-12
clotrimazole 1 uM 16.0534 < 1e-12
latrunculin 0.78 uM 15.5299 0.0020603
synthetic complete for BY4743 0 15.1151 0.0021742
miconazole 50 nM 13.5186 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR093W

Top 10 functional gene interactors with YKR093W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PTR2 by heterozygous co-sensitivity:

Query Interactor Correlation
PTR2 HUA1 0.4489
PTR2 YDL114W 0.44246
PTR2 CPA1 0.40929
PTR2 BTT1 0.3879
PTR2 WSC4 0.3836
PTR2 BRE2 0.37596
PTR2 YDL050C 0.37474
PTR2 MAG2 0.37196
PTR2 YNR064C 0.3663
PTR2 ESC1 0.36526

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PTR2 by homozygous co-sensitivity:

Query Interactor Correlation
PTR2 PDR1 0.71579
PTR2 LAA1 0.48325
PTR2 YPL183C 0.45215
PTR2 HXT12 0.44901
PTR2 HMG1 0.43709
PTR2 DST1 0.4205
PTR2 YGL199C 0.41926
PTR2 TVP18 0.41693
PTR2 BRE2 0.40832
PTR2 ISU1 0.4016

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:




External information about YKR093W

Other databases:

Visit YKR093W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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