Retrieving results for YKR084C, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YKR084C / HBS1



Section 1: Phenotypes.
Gene-drug relationships for YKR084C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR084C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HBS1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
metergoline 250 uM 8.92414 7.1458e-12
bufexamac 1000 uM 6.41949 3.1109e-08
bufexamac 1000 uM 6.39218 3.4226e-08
tryptanthrin 250 uM 5.79827 9.7397e-07
hydroxyurea 50000 uM 5.53881 6.6656e-07
fluconazole 65.3 uM 4.13989 7.1518e-05
itraconazole 17.7 uM 3.87112 0.00016668
amphotericin b 0.31 uM 3.71347 0.00027079
latrunculin 3.91 uM 3.56601 0.00058218
itraconazole 17.7 uM 3.5073 0.00050389

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for HBS1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nacl 1000 uM 7.31974 1.271e-05
nacl 1000 uM 6.81401 2.3298e-05
sorbitol 1.5 M 5.75178 9.2359e-05
synthetic complete for BY4743 0 5.42011 0.00014648
ph8 0 5.26457 0.00018283
sorbitol 1.5e+06 uM 4.69029 0.00042703
licl 100 mM 4.42296 0.00016418
methotrexate 250 uM 4.3142 0.00010262
sorbitol 1.5e+06 uM 4.2433 0.00085374
berberine chloride 125 uM 4.1474 0.00015901

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR084C

Top 10 functional gene interactors with YKR084C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with HBS1 by heterozygous co-sensitivity:

Query Interactor Correlation
HBS1 YNR061C 0.37667
HBS1 SNZ2 0.34044
HBS1 YPL168W 0.33299
HBS1 MMT2 0.33065
HBS1 YER087C-A 0.3289
HBS1 PEP4 0.32614
HBS1 URA8 0.31929
HBS1 YNL321W 0.319
HBS1 YCL076W 0.3175
HBS1 YLR437C 0.31136

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with HBS1 by homozygous co-sensitivity:

Query Interactor Correlation
HBS1 YDR278C 0.4487
HBS1 SKI7 0.43711
HBS1 YGL214W 0.42365
HBS1 BCH2 0.41282
HBS1 YAP1801 0.41002
HBS1 SBP1 0.37539
HBS1 NOP16 0.37334
HBS1 DPL1 0.36444
HBS1 ERV14 0.36353
HBS1 YDR157W 0.35425

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YKR084C

Other databases:

Visit YKR084C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.