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Yeast Fitness
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YKR069W / MET1



Section 1: Phenotypes.
Gene-drug relationships for YKR069W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR069W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MET1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
itraconazole 17.7 uM 4.11375 7.7727e-05
caspofungin 10 nM 4.00238 0.00011057
itraconazole 17.7 uM 3.98343 0.00011736
caspofungin 10 nM 3.74689 0.0002445
trichlormethine 500 uM 3.52701 0.00047517
parthenolide 1000 uM 3.2034 0.0012199
5-fluorocytosine 15.6 uM 3.08229 0.0017156
amphotericin b 0.62 uM 2.88576 0.0029398
lapachol 1000 uM 2.67441 0.0051328
miconazole 100 uM 2.56081 0.0068571

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MET1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 110.011 5.9008e-10
synthetic complete for BY4743 0 97.0876 1.1005e-09
synthetic complete for BY4743 0 51.6411 2.5738e-08
synthetic complete for BY4743 0 47.63 3.8534e-08
synthetic complete for BY4743 0 19.9244 1.0033e-07
synthetic complete for BY4743 0 19.3776 1.2153e-07
minimal media 0 18.4952 2.302e-09
minimal media 0 17.9534 < 1e-12
synthetic complete for BY4743 0 9.74255 1.2701e-05
minimal media 0 9.49932 3.0552e-10

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR069W

Top 10 functional gene interactors with YKR069W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MET1 by heterozygous co-sensitivity:

Query Interactor Correlation
MET1 SAP1 0.36818
MET1 FRE5 0.36622
MET1 YGR266W 0.36299
MET1 LYS21 0.36252
MET1 NAT4 0.36084
MET1 BMH2 0.34742
MET1 FMP23 0.34468
MET1 TDP1 0.3377
MET1 YJR146W 0.33262
MET1 YLR400W 0.32979

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MET1 by homozygous co-sensitivity:

Query Interactor Correlation
MET1 CPA2 0.62327
MET1 ARG5,6 0.62276
MET1 SER2 0.61566
MET1 ARG4 0.59945
MET1 MET17 0.55689
MET1 YER091C-A 0.55424
MET1 LYS1 0.54347
MET1 ARG1 0.53954
MET1 INO2 0.53896
MET1 PHA2 0.53647

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YKR069W

Other databases:

Visit YKR069W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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