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Yeast Fitness
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YKR066C / CCP1



Section 1: Phenotypes.
Gene-drug relationships for YKR066C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR066C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CCP1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
itraconazole 8.8 uM 8.23914 5.7744e-11
econazole 0.12 uM 7.72737 3.2759e-10
alverine citrate 500 uM 6.27255 0.012243
fluconazole 65.3 uM 5.94654 1.6213e-07
rutilantin 500 uM 4.99539 4.2722e-06
lapachol 1000 uM 4.69879 1.1554e-05
solasodine 250 uM 4.5515 1.8816e-05
hydroxyurea 50000 uM 4.50195 2.2146e-05
methotrexate 500 uM 4.31427 4.0838e-05
cloxyquin 15.6 uM 4.30812 4.1659e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for CCP1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
phosphatase inhibitor 3 uM 33.3351 < 1e-12
synthetic complete for BY4743 0 12.5336 0.0031528
synthetic complete for BY4743 0 10.3114 0.00024952
phosphatase inhibitor 2 uM 8.32362 5.124e-10
synthetic complete for BY4743 0 7.05972 0.00044079
synthetic complete for BY4743 0 5.19381 0.006932
fk506 0.05 ug/ml 4.59087 2.8947e-05
licl 100 mM 4.46928 0.00014821
synthetic complete for BY4743 0 3.98582 0.0081608
synthetic complete for BY4743 0 3.95278 0.0054103

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR066C

Top 10 functional gene interactors with YKR066C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CCP1 by heterozygous co-sensitivity:

Query Interactor Correlation
CCP1 VHS1 0.38665
CCP1 ECM25 0.3775
CCP1 ASP1 0.3529
CCP1 KRE27 0.35244
CCP1 IRC10 0.34595
CCP1 OCA5 0.34232
CCP1 YAP5 0.32852
CCP1 ZRG8 0.31893
CCP1 YPR096C 0.31772
CCP1 YPL168W 0.31582

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with CCP1 by homozygous co-sensitivity:

Query Interactor Correlation
CCP1 YNR042W 0.61643
CCP1 TRX2 0.61297
CCP1 CBP3 0.57852
CCP1 COQ9 0.55347
CCP1 QCR9 0.54267
CCP1 QCR8 0.52244
CCP1 CBP2 0.50886
CCP1 CAT5 0.49781
CCP1 MRPS16 0.4948
CCP1 CBS2 0.48094

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YKR066C

Other databases:

Visit YKR066C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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