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Yeast Fitness
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YKR060W / UTP30



Section 1: Phenotypes.
Gene-drug relationships for YKR060W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR060W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for UTP30 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
37 degrees C 0 2.47206 0.01252
floxuridine 3.37 uM 1.70135 0.054113
5-fluorouracil 19.2 uM 1.67707 0.056477
ketoconazole 11.8 uM 1.63622 0.060654
nocodazole 6.6 uM 1.22967 0.1183
nocodazole 6.9 uM 1.14083 0.15281
benomyl 6.9 uM 1.11167 0.15843
benomyl 13.8 uM 1.00296 0.18096
tunicamycin 0.6 uM 0.943738 0.17967
mitotane 100 uM 0.31581 0.37677

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for UTP30 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
phosphatase inhibitor 3 uM 3.67402 0.00040763
wiskostatin 29 uM 3.17574 0.0015859
37 degrees C 0 2.85579 0.004164
methotrexate 250 uM 2.68925 0.0061682
cadmium chloride 7.81 uM 2.66227 0.0058845
rapamycin 9 nM 2.41837 0.047153
synthetic complete for BY4743 0 2.33455 0.026131
methotrexate 250 uM 2.11476 0.022097
cisplatin 125 uM 2.1018 0.022705
synthetic complete for BY4743 0 1.89195 0.077428

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR060W

Top 10 functional gene interactors with YKR060W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

[No heterozygous results.]
 
Homozygous co-fitness interactions

Top 10 interactors with UTP30 by homozygous co-sensitivity:

Query Interactor Correlation
UTP30 RPS28A 0.48876
UTP30 RPS1A 0.47367
UTP30 RPS27A 0.46592
UTP30 RPS22B 0.44092
UTP30 DUS4 0.4281
UTP30 YLR366W 0.42723
UTP30 RPS7B 0.42679
UTP30 RPS14A 0.40803
UTP30 ATC1 0.40585
UTP30 YOR006C 0.39798

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YKR060W

Other databases:

Visit YKR060W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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