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Yeast Fitness
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YKR059W / TIF1



Section 1: Phenotypes.
Gene-drug relationships for YKR059W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR059W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TIF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dna protein kinase inhibitor 0 2.67694 0.0058105
no drug minimal media 0 2.66818 0.022223
thujaplicin alpha 15.63 uM 2.50023 0.0088641
floxuridine 3.37 uM 2.48067 0.012306
thiabendazole 250 uM 2.41791 0.01074
no drug minimal media 0 2.34494 0.032987
cocl2 1250 uM 2.16418 0.019011
methotrexate 500 uM 2.15959 0.019202
fecl4 2500 uM 2.12828 0.020555
acriflavinium hydrochloride 250 uM 2.12335 0.019509

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for TIF1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 14.1448 1.714e-11
thiabendazole 250 uM 10.0694 9.1768e-11
synthetic complete for BY4743 0 9.94767 0.0049774
methotrexate 250 uM 8.43727 3.2141e-09
synthetic complete for BY4743 0 7.41645 0.0025359
cantharidin 200 uM 5.90214 5.7694e-07
benomyl 10 ug/ml 5.85976 0.004955
nocodazole 10 ug/ml 4.50257 0.00013772
synthetic complete for BY4743 0 4.37088 0.024281
allyl disulfide 0.06 % 4.29447 6.9088e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR059W

Top 10 functional gene interactors with YKR059W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TIF1 by heterozygous co-sensitivity:

Query Interactor Correlation
TIF1 ERP6 0.66161
TIF1 YGR015C 0.66158
TIF1 YNL187W 0.65868
TIF1 YJR107W 0.63898
TIF1 ECM3 0.63197
TIF1 PYK2 0.6295
TIF1 HUT1 0.61944
TIF1 RGS2 0.61697
TIF1 YOR152C 0.61459
TIF1 YOL083W 0.61262

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with TIF1 by homozygous co-sensitivity:

Query Interactor Correlation
TIF1 RPS27A 0.48684
TIF1 UBP5 0.42722
TIF1 COY1 0.42397
TIF1 RPS28A 0.41787
TIF1 YLR366W 0.40902
TIF1 YDL010W 0.40833
TIF1 RPS22B 0.40552
TIF1 HTB2 0.39743
TIF1 DUG1 0.39567
TIF1 HOS4 0.38746

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YKR059W

Other databases:

Visit YKR059W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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