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Yeast Fitness
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YKR058W / GLG1



Section 1: Phenotypes.
Gene-drug relationships for YKR058W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR058W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GLG1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 6.25 uM 4.46623 0.00019492
dmso 4% 4 uM 3.86837 0.00016811
atorvastatin 62.5 uM 3.56117 0.00042908
hydroxyurea 50000 uM 3.41253 0.00066662
sulfanilamide 62.5 uM 3.22096 0.0011604
thiabendazole 500 uM 3.16134 0.0013743
lovastatin 62.5 uM 3.03147 0.0019756
mitomycin c 1000 uM 2.98164 0.0022659
usnic acid 500 uM 2.97161 0.0023289
lefunamide 250 uM 2.86949 0.0030712

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GLG1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 4.32098 0.024804
methotrexate 250 uM 3.87117 0.0003268
synthetic complete for BY4743 0 3.16754 0.0050148
synthetic complete for BY4743 0 2.55137 0.019014
wiskostatin 29 uM 2.32462 0.0131
lysine dropout 0 2.30784 0.016926
adenine dropout 0 2.24382 0.019225
mechlorethamine 62.5 uM 1.99609 0.092018
tryptophan dropout 0 1.90974 0.042621
5-fluorouracil 19.2 uM 1.71806 0.058268

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR058W

Top 10 functional gene interactors with YKR058W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GLG1 by heterozygous co-sensitivity:

Query Interactor Correlation
GLG1 YKL105C 0.59902
GLG1 PEX14 0.5943
GLG1 SHE2 0.588
GLG1 DMC1 0.58048
GLG1 STF2 0.56619
GLG1 FAR3 0.56169
GLG1 YKL151C 0.55938
GLG1 YDR541C 0.558
GLG1 FAU1 0.54853
GLG1 MLC2 0.54823

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

Top 10 interactors with GLG1 by homozygous co-sensitivity:

Query Interactor Correlation
GLG1 YDR541C 0.75877
GLG1 YFR045W 0.75479
GLG1 YCL075W 0.74801
GLG1 HXK1 0.74667
GLG1 MGA1 0.73583
GLG1 FOX2 0.72386
GLG1 PES4 0.7207
GLG1 ADH7 0.71516
GLG1 YCL023C 0.71223
GLG1 YMR147W 0.70702

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YKR058W

Other databases:

Visit YKR058W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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