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Yeast Fitness
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YKR055W / RHO4



Section 1: Phenotypes.
Gene-drug relationships for YKR055W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR055W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RHO4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 18.5642 < 1e-12
atorvastatin 125 uM 9.61593 2.1825e-12
drofenine hydrochloride 750 uM 9.51539 2.4006e-12
dmso 4% 4 uM 6.22706 6.0948e-08
thiabendazole 500 uM 6.08611 9.9684e-08
propiomazine maleate 500 uM 5.94054 1.6555e-07
lovastatin 62.5 uM 4.6318 1.4432e-05
methotrexate 500 uM 4.24699 5.0745e-05
nitromide 1000 uM 4.20114 5.8798e-05
5-fluorouracil 125 uM 4.17354 6.4232e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RHO4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 15.5485 < 1e-12
tryptophan dropout 0 7.50845 1.0214e-05
synthetic complete for BY4743 0 7.14888 9.2771e-05
rapamycin 9 nM 5.7195 0.014618
rapamycin 9 nM 5.02777 0.0075802
rapamycin 9 nM 4.86519 0.019873
thiabendazole 250 uM 3.68338 0.00053078
cantharidin 100 uM 3.53246 0.00060397
synthetic complete for BY4743 0 3.37653 0.013937
zncl2 1875 uM 3.30656 0.0011181

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR055W

Top 10 functional gene interactors with YKR055W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RHO4 by heterozygous co-sensitivity:

Query Interactor Correlation
RHO4 ABF1 0.49809
RHO4 YKL111C 0.4954
RHO4 SCY1 0.45496
RHO4 BMH1 0.45121
RHO4 YGL160W 0.40948
RHO4 LSM4 0.40594
RHO4 SWH1 0.4008
RHO4 YER119C-A 0.38415
RHO4 YER130C 0.38408
RHO4 SCS2 0.37897

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RHO4 by homozygous co-sensitivity:

Query Interactor Correlation
RHO4 AQY2 0.74741
RHO4 PEA2 0.71845
RHO4 TOM71 0.71207
RHO4 YLR404W 0.7102
RHO4 YGL079W 0.67639
RHO4 LAG1 0.67292
RHO4 DAL5 0.67242
RHO4 YHR127W 0.662
RHO4 SFK1 0.65651
RHO4 PAA1 0.65383

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YKR055W

Other databases:

Visit YKR055W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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