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Yeast Fitness
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YKR034W / DAL80



Section 1: Phenotypes.
Gene-drug relationships for YKR034W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR034W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for DAL80 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.5 uM 3.21313 0.0027129
alizarin 66 uM 2.25888 0.015419
fk506 50 uM 2.16211 0.019097
mefenamic acid 500 uM 2.12468 0.019451
fk506 100 uM 2.11383 0.021208
floxuridine 3.37 uM 2.108 0.025576
ethoxyquin 250 uM 2.07212 0.021883
papuamide b 0.125 ug/ml 2.05291 0.024166
dihydromotuporamine C 7.5 uM 1.96992 0.028777
alverine citrate 500 uM 1.9556 0.028236

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for DAL80 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fk506 100 uM 6.76019 4.5135e-08
cadmium chloride 7.81 uM 6.28681 1.8313e-07
fk506 200 uM 5.90528 5.7155e-07
mechlorethamine 62.5 uM 5.78291 0.014312
methotrexate 250 uM 5.43923 5.292e-06
mechlorethamine 62.5 uM 4.8635 0.019886
zncl2 1875 uM 4.81488 1.4906e-05
mechlorethamine 62.5 uM 4.62395 0.021863
lovastatin 154.5 uM 4.46844 6.8359e-05
synthetic complete for BY4743 0 4.02754 0.0012045

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR034W

Top 10 functional gene interactors with YKR034W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with DAL80 by heterozygous co-sensitivity:

Query Interactor Correlation
DAL80 MND2 0.73485
DAL80 PYK2 0.73437
DAL80 JIP4_p 0.73049
DAL80 BMS1 0.72964
DAL80 GAD1 0.72667
DAL80 YNL187W 0.72273
DAL80 YOR292C 0.7227
DAL80 IPL1 0.71634
DAL80 GRE1 0.70742
DAL80 EFT1 0.7064

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with DAL80 by homozygous co-sensitivity:

Query Interactor Correlation
DAL80 YGL177W 0.4863
DAL80 YOR1 0.46087
DAL80 SPO14 0.45553
DAL80 YNL187W 0.42387
DAL80 ICE2 0.41015
DAL80 THR4 0.4058
DAL80 GDH2 0.40312
DAL80 MKT1 0.39944
DAL80 PDR17 0.39071
DAL80 KAR5 0.38215

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YKR034W

Other databases:

Visit YKR034W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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