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YKR029C / SET3



Section 1: Phenotypes.
Gene-drug relationships for YKR029C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR029C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SET3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
itraconazole 4.4 uM 8.84145 8.9113e-12
no drug minimal media 0 6.97578 0.00021576
itraconazole 17.7 uM 6.36451 3.7702e-08
cloxyquin 15.6 uM 6.34683 4.0106e-08
bufexamac 1000 uM 6.13298 8.4647e-08
no drug minimal media 0 5.19398 0.0017422
itraconazole 17.7 uM 5.17641 2.3108e-06
itraconazole 8.8 uM 4.99645 4.2568e-06
ID 693632 62.5 uM 4.67135 2.576e-05
5-fluorocytosine 15.6 uM 4.27728 4.6025e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SET3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 200 uM 24.7965 < 1e-12
nocodazole 10 ug/ml 20.3284 < 1e-12
k2cr2o7 125 uM 15.4819 < 1e-12
synthetic complete for BY4743 0 11.3835 2.3948e-07
licl 100 mM 11.1312 8.3773e-10
tryptanthrin 250 uM 10.56 < 1e-12
psoralen 62.5 uM 7.68079 3.1293e-09
licl 150 mM 7.67695 3.1638e-09
licl 150 mM 7.58785 4.081e-09
ID 604586 31.25 uM 7.19948 1.2501e-08

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR029C

Top 10 functional gene interactors with YKR029C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SET3 by heterozygous co-sensitivity:

Query Interactor Correlation
SET3 BIO4 0.45155
SET3 PML1 0.43954
SET3 ATE1 0.43735
SET3 ERP3 0.428
SET3 YHR022C 0.42269
SET3 TWF1 0.41744
SET3 CIN4 0.41595
SET3 YKR104W 0.41373
SET3 DIB1 0.41038
SET3 CNA1 0.40622

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SET3 by homozygous co-sensitivity:

Query Interactor Correlation
SET3 SNT1 0.76511
SET3 HOS2 0.75789
SET3 SIF2 0.64373
SET3 HOS4 0.55542
SET3 BUD3_p 0.38333
SET3 TRM8 0.38286
SET3 DAK2 0.37397
SET3 HXT3 0.37161
SET3 GRE1 0.37077
SET3 SNX41 0.36947

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YKR029C

Other databases:

Visit YKR029C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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