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Yeast Fitness
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YKR026C / GCN3



Section 1: Phenotypes.
Gene-drug relationships for YKR026C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKR026C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GCN3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 6.07822 0.00045053
itraconazole 17.7 uM 4.93605 5.2196e-06
thiabendazole 500 uM 4.51822 2.0993e-05
itraconazole 17.7 uM 4.08979 8.3877e-05
resveratrol 2000 uM 3.25802 0.0013293
4-isopropyltropolone 15.63 uM 3.17552 0.0016506
cantharidin 250 uM 3.09686 0.04518
bufexamac 1000 uM 3.07273 0.0017619
dyclonine 500 uM 3.02157 0.0020303
parthenolide 1000 uM 2.65593 0.0053831

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GCN3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 110.579 4.0885e-05
synthetic complete for BY4743 0 81.3519 7.5533e-05
tryptophan dropout 0 46.9667 < 1e-12
synthetic complete for BY4743 0 26.5371 5.8704e-05
synthetic complete for BY4743 0 22.0283 0.0010272
zncl2 1875 uM 21.0454 < 1e-12
miconazole 50 nM 19.0007 < 1e-12
synthetic complete for BY4743 0 18.0541 4.7888e-06
miconazole 50 nM 17.2846 < 1e-12
lovastatin 154.5 uM 13.323 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKR026C

Top 10 functional gene interactors with YKR026C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GCN3 by heterozygous co-sensitivity:

Query Interactor Correlation
GCN3 DMC1 0.62764
GCN3 FAR3 0.62646
GCN3 SHE2 0.62169
GCN3 YGR001C 0.59475
GCN3 ATG2 0.58369
GCN3 YKL105C 0.58072
GCN3 DIE2 0.58014
GCN3 YKR012C 0.57414
GCN3 YGL260W 0.57399
GCN3 YER187W 0.56612

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GCN3 by homozygous co-sensitivity:

Query Interactor Correlation
GCN3 GCN4 0.76162
GCN3 TRP3 0.6591
GCN3 GCN2 0.62441
GCN3 UPC2 0.61354
GCN3 GCN20 0.53845
GCN3 TRP1 0.52828
GCN3 ENT4 0.49624
GCN3 PDR16 0.47561
GCN3 ARO3 0.47307
GCN3 TVP18 0.46487

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YKR026C

Other databases:

Visit YKR026C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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