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Yeast Fitness
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YKL216W / URA1



Section 1: Phenotypes.
Gene-drug relationships for YKL216W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKL216W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for URA1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 6.15245 0.00042261
sanguinarine sulfate 250 uM 6.14474 8.1244e-08
no drug minimal media 0 6.09502 0.0008603
dna protein kinase inhibitor 0 4.2364 8.9735e-05
no drug minimal media 0 4.19623 0.0042602
dihydromotuporamine C 15 uM 4.07999 0.00013979
itraconazole 4.4 uM 3.90475 0.00015012
mecysteine hydrochloride 62.5 uM 3.47115 0.0005609
no drug minimal media 0 3.32222 0.0079801
benztropine 1 uM 3.26699 0.0010172

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for URA1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 16.0623 8.5187e-06
chemdiv 275 62 uM 12.8668 < 1e-12
synthetic complete for BY4743 0 10.5827 0.00022559
mms 0.002 % 9.30298 3.5883e-11
synthetic complete for BY4743 0 8.38861 0.00019718
nitric oxide 800 uM 8.25138 4.9273e-09
synthetic complete for BY4743 0 8.06313 5.4954e-06
synthetic complete for BY4743 0 7.7241 0.00029043
synthetic complete for BY4743 0 7.71084 0.00076124
synthetic complete for BY4743 0 7.55115 0.00032276

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKL216W

Top 10 functional gene interactors with YKL216W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with URA1 by heterozygous co-sensitivity:

Query Interactor Correlation
URA1 YCR007C 0.51214
URA1 VAC17 0.51107
URA1 FUS1 0.49668
URA1 ADP1 0.48872
URA1 YCL049C 0.4869
URA1 CWH41 0.48541
URA1 LSB5 0.4796
URA1 HIS4 0.47879
URA1 RPC37 0.47612
URA1 MRC1 0.47538

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with URA1 by homozygous co-sensitivity:

Query Interactor Correlation
URA1 YGR182C 0.57349
URA1 TIM13 0.41942
URA1 MRP49 0.41741
URA1 TOM6 0.4078
URA1 YCR006C 0.40593
URA1 DAP1 0.39235
URA1 YPL041C 0.38745
URA1 YPL182C 0.38254
URA1 IOC4 0.38186
URA1 IZH2 0.37522

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YKL216W

Other databases:

Visit YKL216W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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