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Yeast Fitness

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YKL186C / MTR2

Section 1: Phenotypes.
Gene-drug relationships for YKL186C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKL186C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MTR2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 4.75007 2.0516e-05
clozapine 500 uM 4.68279 1.2186e-05
latrunculin 1.95 uM 3.79043 0.00031431
alverine citrate 500 uM 3.31875 0.00087615
alverine citrate 500 uM 3.31474 0.00088636
filipin 100 uM 2.73466 0.0050471
wiskostatin 29 uM 2.71821 0.0052545
benomyl 6.9 uM 2.55505 0.025476
metergoline 250 uM 2.53932 0.0072374
alverine citrate 500 uM 2.4458 0.0091262

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YKL186C

Top 10 functional gene interactors with YKL186C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with MTR2 by heterozygous co-sensitivity:

Query Interactor Correlation
MTR2 UTP20 0.67586
MTR2 DUO1 0.67133
MTR2 SRP21 0.66072
MTR2 NPT1 0.65047
MTR2 PRS1 0.64518
MTR2 YGR251W 0.64379
MTR2 APC5 0.63766
MTR2 SCC2 0.63637
MTR2 PRP24 0.63388
MTR2 DBP7 0.63075

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YKL186C

Other databases:

Visit YKL186C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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