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Yeast Fitness
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YKL119C / VPH2



Section 1: Phenotypes.
Gene-drug relationships for YKL119C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKL119C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for VPH2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 19.3086 3.4365e-06
no drug minimal media 0 18.5444 4.1954e-06
no drug minimal media 0 16.3743 7.7492e-06
no drug minimal media 0 15.9917 1.8987e-06
no drug minimal media 0 15.3053 1.0799e-05
no drug minimal media 0 13.9629 4.2059e-06
no drug minimal media 0 13.5866 1.9357e-05
no drug minimal media 0 13.2393 5.7372e-06
no drug minimal media 0 10.8553 1.8104e-05
no drug minimal media 0 6.86983 0.00049966

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for VPH2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 4.88716 5.9298e-05
curcumin 150 uM 4.5499 0.00012407
angelicin 62.5 uM 4.07406 0.00035608
bisphenol 125 uM 3.96662 0.00045232
latrunculin 0.78 uM 3.80579 0.0006473
benzaldehyde 0.003 % 2.93484 0.0044263
carboplatin 15000 uM 2.93134 0.00446
synthetic complete for BY4743 0 2.86883 0.022761
papuamide b 0.7 ug/ml 2.77718 0.0062147
synthetic complete for BY4743 0 2.7245 0.026371

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKL119C

Top 10 functional gene interactors with YKL119C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with VPH2 by heterozygous co-sensitivity:

Query Interactor Correlation
VPH2 BUR6 0.59036
VPH2 SDH4 0.59013
VPH2 YPR177C 0.56509
VPH2 YGR102C 0.54754
VPH2 RAD27 0.54622
VPH2 SLY1 0.53295
VPH2 LSM5 0.53221
VPH2 UTP11 0.52975
VPH2 CCA1 0.52692
VPH2 URA6 0.51912

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YKL119C

Other databases:

Visit YKL119C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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