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Yeast Fitness

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YKL104C / GFA1

Section 1: Phenotypes.
Gene-drug relationships for YKL104C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKL104C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GFA1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 27.696 < 1e-12
phenanthroline monohydrochloride 62.5 uM 26.826 < 1e-12
wiskostatin 19 uM 17.537 < 1e-12
tunicamycin 0.15 uM 11.2536 4.8391e-05
methotrexate 250 uM 6.55985 1.9041e-08
tunicamycin 0.6 uM 6.39098 0.00069465
caspofungin 10 nM 5.54239 6.5837e-07
caspofungin 10 nM 5.14886 2.5382e-06
caspofungin 10 nM 4.85456 6.8657e-06
dna protein kinase inhibitor 0 4.75395 2.0287e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YKL104C

Top 10 functional gene interactors with YKL104C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with GFA1 by heterozygous co-sensitivity:

Query Interactor Correlation
GFA1 DIG2 0.49654
GFA1 YGR190C 0.44436
GFA1 YKL111C 0.44139
GFA1 RRN10 0.43573
GFA1 TAF10 0.3919
GFA1 SRB5 0.39128
GFA1 LSM4 0.38872
GFA1 ABF1 0.37955
GFA1 SEC9 0.37645
GFA1 DAM1 0.37495

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YKL104C

Other databases:

Visit YKL104C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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