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Yeast Fitness
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YKL081W / TEF4



Section 1: Phenotypes.
Gene-drug relationships for YKL081W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKL081W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TEF4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.5 uM 3.06394 0.0037096
terbinafine 7.2 uM 3.05631 0.0049835
papuamide b 0.125 ug/ml 2.65027 0.0061983
ID 632839 62.5 uM 2.57326 0.0074567
Tyrphostin 6.2 uM 2.57112 0.0074949
prazosin hydrochloride 1000 uM 2.31142 0.012621
atorvastatin 125 uM 2.2732 0.013813
benomyl 13.8 uM 2.15094 0.042072
benomyl 6.9 uM 2.03631 0.048663
beclomethasone dipropionate 1000 uM 2.02158 0.024467

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for TEF4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
allyl disulfide 0.06 % 13.1372 < 1e-12
licl 150 mM 9.21185 4.5718e-11
licl 150 mM 9.13041 5.6817e-11
hydroxyurea 25000 uM 7.35841 7.8919e-09
synthetic complete for BY4743 0 5.80875 8.5456e-05
rapamycin 6 nM 5.48224 2.029e-06
synthetic complete for BY4743 0 5.16109 0.00021228
wiskostatin 19 uM 4.80266 1.5458e-05
isoleucine dropout 0 4.70823 0.00010132
chemdiv 41 500 uM 4.68949 2.1625e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKL081W

Top 10 functional gene interactors with YKL081W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TEF4 by heterozygous co-sensitivity:

Query Interactor Correlation
TEF4 ADR1 0.56775
TEF4 YKL088W 0.50436
TEF4 VPS51 0.50317
TEF4 GTS1 0.47957
TEF4 MRPL13 0.46143
TEF4 SCW11 0.45696
TEF4 MGR1 0.45346
TEF4 OSW1 0.45154
TEF4 SCS3 0.44735
TEF4 NAT5 0.44727

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with TEF4 by homozygous co-sensitivity:

Query Interactor Correlation
TEF4 SIR1 0.50815
TEF4 YJR146W 0.45606
TEF4 CLB4 0.45433
TEF4 YMR118C 0.4447
TEF4 CDA1 0.42914
TEF4 GAL2 0.42498
TEF4 KAR5 0.42226
TEF4 SSP2 0.41709
TEF4 WAR1 0.41096
TEF4 YER067C-A 0.39883

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YKL081W

Other databases:

Visit YKL081W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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