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YKL057C / NUP120



Section 1: Phenotypes.
Gene-drug relationships for YKL057C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKL057C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for NUP120 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 19.2 uM 5.27891 3.7451e-05
methotrexate 250 uM 3.23761 0.0011065
methotrexate 250 uM 3.11448 0.001568
caspofungin 10 nM 2.79911 0.0037049
itraconazole 17.7 uM 2.68882 0.0049452
hydroxyurea 25000 uM 2.66857 0.0052106
probucol 1000 uM 2.57602 0.0065991
rutilantin 500 uM 2.46 0.0088132
mechlorethamine 250 uM 2.45903 0.0088344
caspofungin 50 nM 2.44786 0.0090802

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for NUP120 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 7.45348 3.3065e-07
myriocin 0.2 ug/ml 3.78556 0.00067714
latrunculin 0.78 uM 3.16748 0.002665
latrunculin 0.78 uM 3.07244 0.045805
synthetic complete for BY4743 0 3.05014 0.027711
rapamycin 9 nM 3.02024 0.047183
licl 100 mM 3.00895 0.0037687
mechlorethamine 62.5 uM 2.65908 0.058551
psoralen 0.5 uM 2.39325 0.013905
licl 100 mM 2.0309 0.028652

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YKL057C

Top 10 functional gene interactors with YKL057C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with NUP120 by heterozygous co-sensitivity:

Query Interactor Correlation
NUP120 RPO26 0.35481
NUP120 NUP145 0.34236
NUP120 RPS27B 0.33332
NUP120 RPL17A 0.33208
NUP120 NUP84 0.33111
NUP120 RPS19B 0.32486
NUP120 RRP9 0.31001
NUP120 RPS29B 0.30259
NUP120 YPR136C 0.30148
NUP120 RPS11A 0.29832

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YKL057C

Other databases:

Visit YKL057C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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