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Yeast Fitness

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YKL035W / UGP1

Section 1: Phenotypes.
Gene-drug relationships for YKL035W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YKL035W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for UGP1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
telomerase inhibitor ix (Biomol) 500 uM 8.04212 1.7516e-09
methotrexate 500 uM 4.8048 1.7509e-05
methotrexate 125 uM 4.3118 7.2382e-05
wiskostatin 29 uM 4.27386 8.0656e-05
tryptanthrin 250 uM 4.26925 8.1721e-05
methotrexate 500 uM 4.21364 9.5733e-05
methotrexate 125 uM 4.04328 0.00015504
chemical diversity labs 3f2 12.5 uM 3.92337 0.00021708
dyclonine 500 uM 3.87288 0.0011081
cantharidin analog 125 uM 3.39433 0.00092536

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YKL035W

Top 10 functional gene interactors with YKL035W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with UGP1 by heterozygous co-sensitivity:

Query Interactor Correlation
UGP1 POL12 0.83627
UGP1 LTV1 0.80216
UGP1 YDR196C 0.79515
UGP1 YGR251W 0.78501
UGP1 URB1 0.78061
UGP1 SLD3 0.77572
UGP1 YGL074C 0.77178
UGP1 NAB2 0.77157
UGP1 PRP40 0.75906
UGP1 IPI3 0.75719

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YKL035W

Other databases:

Visit YKL035W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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