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Yeast Fitness
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YJR145C / RPS4A



Section 1: Phenotypes.
Gene-drug relationships for YJR145C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJR145C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPS4A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 9.92895 1.5165e-08
ketoconazole 11.8 uM 9.5979 2.4236e-08
nocodazole 2 ug/ml 7.03765 3.585e-09
drofenine hydrochloride 750 uM 5.84312 2.3231e-07
metergoline 250 uM 4.66853 1.2777e-05
alverine citrate 500 uM 4.62187 0.00029414
clozapine 500 uM 4.42047 2.8916e-05
tunicamycin 0.15 uM 3.4322 0.0017098
propiomazine maleate 500 uM 3.37834 0.00073679
methotrexate 500 uM 2.3704 0.011981

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPS4A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 10.2861 2.8877e-09
synthetic complete for BY4743 0 2.89434 0.031395
licl 100 mM 2.38274 0.014207
bisphenol 125 uM 2.03463 0.028446
thimerosal 125 nM 1.94734 0.033633
synthetic complete for BY4743 0 1.58222 0.12721
23 degrees C 0 1.45153 0.088636
ph4 7.5 1.28696 0.10721
psoralen 0.5 uM 1.23728 0.11594
curcumin 150 uM 1.14679 0.13324

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJR145C

Top 10 functional gene interactors with YJR145C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPS4A by heterozygous co-sensitivity:

Query Interactor Correlation
RPS4A RPS27B 0.68594
RPS4A UTP4 0.66721
RPS4A RPS3 0.66068
RPS4A YPR136C 0.65574
RPS4A UTP18 0.6395
RPS4A FYV1 0.63949
RPS4A RPS23B 0.63505
RPS4A RPS24A 0.62839
RPS4A RPS20 0.62745
RPS4A RPS18A 0.62693

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YJR145C

Other databases:

Visit YJR145C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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