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Yeast Fitness
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YJR104C / SOD1



Section 1: Phenotypes.
Gene-drug relationships for YJR104C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJR104C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SOD1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
tomatine 62.5 uM 5.25358 1.7758e-06
licl 150 mM 3.84548 0.00026976
cisplatin 1000 uM 2.95503 0.0024368
fluconazole 65.3 uM 2.88671 0.0029323
tryptanthrin 250 uM 2.77936 0.0045213
fk506 0.1 ug/ml 2.63989 0.0063555
lapachol 500 uM 2.58152 0.0065079
bufexamac 1000 uM 2.49898 0.0080036
fk506 0.1 ug/ml 2.43905 0.010226
bufexamac 1000 uM 2.3811 0.010682

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SOD1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 11.4717 5.1908e-10
synthetic complete for BY4743 0 11.4594 0.00016548
benomyl 10 ug/ml 10.0375 4.2153e-09
synthetic complete for BY4743 0 9.51203 0.00034095
synthetic complete for BY4743 0 8.69541 0.00016641
hydroxyurea 200000 uM 8.18299 8.8661e-08
hydroxyurea 50000 uM 8.05563 1.11e-07
synthetic complete for BY4743 0 7.71838 0.00029144
ph4 7.5 7.67035 2.2194e-07
synthetic complete for BY4743 0 7.5757 0.00031792

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJR104C

Top 10 functional gene interactors with YJR104C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SOD1 by heterozygous co-sensitivity:

Query Interactor Correlation
SOD1 RPM2 0.53581
SOD1 NBP1 0.53462
SOD1 RRB1 0.49704
SOD1 FAS2 0.49667
SOD1 GAB1 0.49523
SOD1 PPA2 0.49049
SOD1 NUD1 0.48991
SOD1 MRP7 0.48359
SOD1 BBP1 0.47654
SOD1 DBP10 0.47489

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YJR104C

Other databases:

Visit YJR104C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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