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Yeast Fitness
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YJR090C / GRR1



Section 1: Phenotypes.
Gene-drug relationships for YJR090C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJR090C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GRR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 9.7242 2.237e-11
drofenine hydrochloride 750 uM 6.94507 4.9527e-09
methotrexate 500 uM 6.35835 1.931e-07
itraconazole 17.7 uM 5.07964 3.2115e-06
miconazole 100 uM 5.01326 4.0216e-06
itraconazole 17.7 uM 4.56844 1.7794e-05
methotrexate 500 uM 4.5579 3.5735e-05
5-fluorocytosine 15.6 uM 4.46551 2.4957e-05
k2cr2o7 6.25 uM 4.34908 6.507e-05
metergoline 250 uM 4.07556 8.7752e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GRR1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 6.03231 5.2745e-06
ph4 7.5 5.15839 3.299e-05
ph4 7.5 4.87354 6.1081e-05
synthetic complete for BY4743 0 4.83903 0.00093993
synthetic complete for BY4743 0 4.42651 0.0015286
latrunculin 0.78 uM 4.14118 0.00030669
synthetic complete for BY4743 0 4.0849 0.0075189
synthetic complete for BY4743 0 3.22522 0.01606
curcumin 150 uM 3.16056 0.0027058
benomyl 10 ug/ml 2.71141 0.036539

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJR090C

Top 10 functional gene interactors with YJR090C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GRR1 by heterozygous co-sensitivity:

Query Interactor Correlation
GRR1 BET4 0.49541
GRR1 MDM10 0.47598
GRR1 MRS6 0.46049
GRR1 ATP15 0.45909
GRR1 YDJ1 0.45788
GRR1 FIP1 0.44637
GRR1 TAF11 0.44503
GRR1 ATM1 0.44168
GRR1 BEM4 0.43921
GRR1 SMC2 0.43775

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YJR090C

Other databases:

Visit YJR090C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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