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YJR076C / CDC11

Section 1: Phenotypes.
Gene-drug relationships for YJR076C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJR076C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CDC11 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
bufexamac 1000 uM 13.3575 < 1e-12
itraconazole 17.7 uM 7.27893 1.5467e-09
caspofungin 10 nM 5.70455 3.7577e-07
itraconazole 17.7 uM 4.66535 1.2912e-05
clotrimazole 1 uM 4.62429 1.4795e-05
metergoline 250 uM 4.20016 5.8983e-05
5-fluorocytosine 15.6 uM 4.189 6.1129e-05
drofenine hydrochloride 750 uM 4.01261 0.00010707
5-fluorocytosine 15.6 uM 3.85245 0.00017661
miconazole 100 uM 3.65714 0.00032137

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YJR076C

Top 10 functional gene interactors with YJR076C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with CDC11 by heterozygous co-sensitivity:

Query Interactor Correlation
CDC11 RDS3 0.60705
CDC11 APC5 0.6046
CDC11 YJL032W 0.5921
CDC11 CAF17 0.59135
CDC11 PRP24 0.58554
CDC11 RNA1 0.58031
CDC11 SDH3 0.57763
CDC11 YOR060C 0.57759
CDC11 ATP12 0.57545
CDC11 BUD14 0.57143

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YJR076C

Other databases:

Visit YJR076C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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