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Yeast Fitness
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YJR067C / YAE1



Section 1: Phenotypes.
Gene-drug relationships for YJR067C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJR067C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YAE1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorocytosine 15.6 uM 3.22284 0.0011542
lapachol 1000 uM 3.13842 0.001466
dmso 4% 4 uM 2.86247 0.0031296
tolfenamic acid 1000 uM 2.70331 0.0047628
solasodine 250 uM 2.48907 0.0082029
fluconazole 130.6 uM 2.19427 0.016597
mechlorethamine 500 uM 2.16487 0.017754
itraconazole 17.7 uM 2.10128 0.020503
lovastatin 77.2 uM 2.04223 0.023381
itraconazole 4.4 uM 1.99924 0.025691

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YJR067C

Top 10 functional gene interactors with YJR067C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YAE1 by heterozygous co-sensitivity:

Query Interactor Correlation
YAE1 VAS1 0.61745
YAE1 PAM16 0.60173
YAE1 PAM18 0.58303
YAE1 PPA2 0.58222
YAE1 SFT1 0.57181
YAE1 GAB1 0.5658
YAE1 PPT2 0.56253
YAE1 UME6 0.56197
YAE1 HMO1 0.55824
YAE1 SRP54 0.55638

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YJR067C

Other databases:

Visit YJR067C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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