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Yeast Fitness

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YJR065C / ARP3

Section 1: Phenotypes.
Gene-drug relationships for YJR065C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJR065C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ARP3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
amphotericin b 10 uM 18.472 < 1e-12
nystatin 5 uM 15.5715 < 1e-12
alverine citrate 500 uM 11.8769 2.7121e-08
miconazole 0.2 uM 9.3052 3.7048e-08
sodium fluoride 20000 uM 7.46418 8.5059e-09
wiskostatin 29 uM 7.27459 1.4404e-08
caspofungin 10 nM 7.25268 1.6946e-09
fk506 0.05 ug/ml 6.8559 4.6715e-08
nacl 600 mM 6.54812 1.1211e-07
caspofungin 10 nM 6.28821 4.9225e-08

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YJR065C

Top 10 functional gene interactors with YJR065C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with ARP3 by heterozygous co-sensitivity:

Query Interactor Correlation
ARP3 ARC19 0.60576
ARP3 ARP2 0.56126
ARP3 ARC18 0.55403
ARP3 CPR7 0.52536
ARP3 TYS1 0.51922
ARP3 PGA3 0.50677
ARP3 BET2 0.5051
ARP3 POL2 0.49092
ARP3 RFA2 0.4863
ARP3 URE2 0.48187

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YJR065C

Other databases:

Visit YJR065C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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