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Yeast Fitness
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YJR053W / BFA1



Section 1: Phenotypes.
Gene-drug relationships for YJR053W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJR053W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BFA1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dihydromotuporamine C 15 uM 6.28975 2.3519e-07
miconazole 0.2 uM 6.13071 7.2423e-06
dyclonine 500 uM 4.68347 1.2158e-05
metergoline 250 uM 4.38811 3.2134e-05
no drug minimal media 0 3.57863 0.0079489
itraconazole 4.4 uM 3.39512 0.00070151
aureobasidin a 0.02 ug/ml 3.29767 0.001197
ID 693632 62.5 uM 3.22113 0.0014648
5-fluorouracil 76.8 uM 3.05027 0.0022835
bufexamac 1000 uM 2.78638 0.0038317

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BFA1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mitomycin c 1000 uM 25.0353 < 1e-12
nocodazole 10 ug/ml 20.797 < 1e-12
nocodazole 10 ug/ml 18.6911 < 1e-12
rapamycin 9 nM 16.2406 0.001885
synthetic complete for BY4743 0 12.1607 0.0033472
fk506 0.1 ug/ml 8.18286 7.5835e-10
mechlorethamine 62.5 uM 7.40865 0.0088678
mitomycin c 1000 uM 6.91883 1.2021e-07
sorbitol 1.5e+06 uM 6.16076 8.1424e-07
fk506 0.05 ug/ml 5.80053 7.8193e-07

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJR053W

Top 10 functional gene interactors with YJR053W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BFA1 by heterozygous co-sensitivity:

Query Interactor Correlation
BFA1 PDR11 0.503
BFA1 YNL058C 0.45482
BFA1 HAM1 0.4538
BFA1 YGR201C 0.4517
BFA1 GLC3 0.44559
BFA1 YOR041C 0.43547
BFA1 SWH1_p 0.4292
BFA1 OSM1 0.42091
BFA1 DLS1 0.42019
BFA1 YPR117W 0.4193

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with BFA1 by homozygous co-sensitivity:

Query Interactor Correlation
BFA1 BUB2 0.8221
BFA1 MAD2 0.55509
BFA1 MAD3 0.53758
BFA1 CPR2 0.53438
BFA1 YIL057C 0.53267
BFA1 YPL245W 0.50561
BFA1 PFK26 0.49396
BFA1 MAD1 0.4914
BFA1 YGL108C 0.48297
BFA1 YHR022C 0.4728

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YJR053W

Other databases:

Visit YJR053W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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