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Yeast Fitness
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YJR010W / MET3



Section 1: Phenotypes.
Gene-drug relationships for YJR010W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJR010W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MET3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 7.40309 0.00035387
no drug minimal media 0 5.84787 0.0010352
no drug minimal media 0 5.62431 0.0012304
no drug minimal media 0 5.398 0.0014735
no drug minimal media 0 4.95165 0.0021394
5-fluorouracil 38.5 uM 3.18945 0.0028514
no drug minimal media 0 3.1782 0.012294
5-fluorouracil 19.2 uM 2.94186 0.0047856
no drug minimal media 0 2.82057 0.018542
alizarin 66 uM 2.80714 0.0042209

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MET3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 63.4089 9.2351e-09
synthetic complete for BY4743 0 61.3463 1.0893e-08
synthetic complete for BY4743 0 54.6637 1.9376e-08
synthetic complete for BY4743 0 53.867 2.0849e-08
synthetic complete for BY4743 0 39.4931 8.7068e-10
synthetic complete for BY4743 0 33.85 2.5461e-09
minimal media 0 20.6157 7.9759e-10
cadmium chloride 7.81 uM 15.0967 < 1e-12
synthetic complete for BY4743 0 12.8161 2.042e-06
mms 0.002 % 11.3725 0.0038217

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJR010W

Top 10 functional gene interactors with YJR010W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MET3 by heterozygous co-sensitivity:

Query Interactor Correlation
MET3 PYK2 0.72724
MET3 PDH1 0.72425
MET3 HUT1 0.70567
MET3 DAK1 0.70511
MET3 YNL187W 0.69799
MET3 YOL083W 0.69352
MET3 MND2 0.69326
MET3 LCB4 0.693
MET3 SVS1 0.68055
MET3 YOR378W 0.67542

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with MET3 by homozygous co-sensitivity:

Query Interactor Correlation
MET3 ARG4 0.75642
MET3 CPA2 0.72928
MET3 ORT1 0.63997
MET3 PHA2 0.6105
MET3 ARG1 0.60816
MET3 YGR122C-A 0.58902
MET3 YLR456W 0.57623
MET3 GSM1 0.54799
MET3 YPR077C 0.5447
MET3 ARG5,6 0.54425

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YJR010W

Other databases:

Visit YJR010W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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