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Yeast Fitness
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YJL210W / PEX2



Section 1: Phenotypes.
Gene-drug relationships for YJL210W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL210W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PEX2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 8.49638 1.2589e-07
fluconazole 130.6 uM 7.17539 2.2178e-09
itraconazole 17.7 uM 6.88874 6.0297e-09
itraconazole 17.7 uM 6.64834 1.3973e-08
miconazole 25 nM 5.40518 1.0561e-06
methotrexate 500 uM 5.0964 7.5071e-06
hydroxyurea 25000 uM 4.84092 7.1873e-06
paraquat 2000 uM 4.78716 1.8427e-05
lovastatin 77.2 uM 4.66064 1.3116e-05
anisomycin 62.5 uM 4.55281 1.8735e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PEX2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 101.354 4.8665e-05
rapamycin 9 nM 39.1041 0.00032666
mechlorethamine 62.5 uM 37.0569 0.00036371
rapamycin 9 nM 17.6292 0.00019895
mechlorethamine 62.5 uM 13.3389 0.0027867
nitric oxide 800 uM 11.5984 4.4396e-12
mechlorethamine 62.5 uM 11.0518 0.004044
mms 0.002 % 10.6937 0.0043158
cadmium chloride 7.81 uM 8.41492 3.9787e-10
mechlorethamine 62.5 uM 8.20761 0.0018926

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL210W

Top 10 functional gene interactors with YJL210W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PEX2 by heterozygous co-sensitivity:

Query Interactor Correlation
PEX2 INO4 0.3633
PEX2 NTG1 0.3486
PEX2 YJR061W 0.33334
PEX2 ICL2 0.32851
PEX2 YJL213W 0.32778
PEX2 DAN3 0.32575
PEX2 IES5 0.31745
PEX2 ERV25 0.31266
PEX2 CIN4 0.30663
PEX2 YPL071C 0.30478

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PEX2 by homozygous co-sensitivity:

Query Interactor Correlation
PEX2 OPT1 0.93255
PEX2 YJL217W 0.47228
PEX2 GPB1 0.44107
PEX2 XBP1 0.42662
PEX2 PMT3 0.4264
PEX2 FMP12 0.4248
PEX2 YDL089W 0.41904
PEX2 ACF4 0.40731
PEX2 MDM36 0.40351
PEX2 PDE2 0.40335

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YJL210W

Other databases:

Visit YJL210W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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