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Yeast Fitness
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YJL188C / BUD19



Section 1: Phenotypes.
Gene-drug relationships for YJL188C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL188C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BUD19 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
progesterone 1000 uM 2.06005 0.047214
23 degrees C 0 2.02979 0.049069
23 degrees C 0 1.57594 0.08793
5-fluorouracil 19.2 uM 1.39299 0.091339
miconazole 0.2 uM 0.977237 0.1715
mitotane 100 uM 0.809841 0.21106
5-fluorouracil 38.5 uM 0.804202 0.21653
nocodazole 6.6 uM 0.52091 0.31233
23 degrees C 0 0.476854 0.31996
hygromycin 0.4 uM 0.330133 0.37279

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BUD19 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 14.8545 7.586e-12
rapamycin 9 nM 5.41194 0.016244
latrunculin 0.78 uM 2.26905 0.017899
latrunculin 0.78 uM 2.07964 0.064524
bisphenol 125 uM 2.06604 0.026763
latrunculin 0.78 uM 1.82998 0.10437
rapamycin 9 nM 1.80375 0.084522
no drug irradiated 0 1.17279 0.12808
benzaldehyde 0.003 % 1.14499 0.1336
papuamide b 0.7 ug/ml 1.13825 0.13497

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL188C

Top 10 functional gene interactors with YJL188C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

[No heterozygous results.]
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YJL188C

Other databases:

Visit YJL188C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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