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Yeast Fitness
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YJL187C / SWE1



Section 1: Phenotypes.
Gene-drug relationships for YJL187C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL187C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SWE1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 16.521 < 1e-12
methotrexate 500 uM 16.505 < 1e-12
mycophenolic acid 500 uM 8.66327 1.4905e-11
miconazole 0.2 uM 7.77053 4.0363e-07
miconazole 25 nM 7.6046 5.0013e-10
cantharidin 250 uM 5.96159 0.013501
metergoline 250 uM 5.06852 3.335e-06
itraconazole 4.4 uM 5.05238 3.5226e-06
bufexamac 1000 uM 4.6429 1.391e-05
bufexamac 1000 uM 4.49612 2.2574e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SWE1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
l-dopa 12.5 ug/ml 14.4537 < 1e-12
sorbitol 1.5e+06 uM 10.6498 2.8124e-11
lovastatin 154.5 uM 8.34262 3.9929e-09
mncl2 2 mM 8.24752 6.3319e-10
cadmium chloride 7.81 uM 6.95928 2.5171e-08
synthetic complete for BY4743 0 6.27579 0.0040841
wiskostatin 29 uM 5.71506 1.01e-06
ph8 0 5.41591 0.00014735
allyl disulfide 0.06 % 5.35055 3.0105e-06
minimal media 0 4.77277 3.0613e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL187C

Top 10 functional gene interactors with YJL187C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SWE1 by heterozygous co-sensitivity:

Query Interactor Correlation
SWE1 ECM25 0.4145
SWE1 SYT1 0.40453
SWE1 FIR1 0.38139
SWE1 FMP12 0.37553
SWE1 FMP27 0.37303
SWE1 RPL1A 0.36935
SWE1 YGL059W 0.36552
SWE1 YHR131C 0.36461
SWE1 PUS4 0.36225
SWE1 CSM4 0.35647

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SWE1 by homozygous co-sensitivity:

Query Interactor Correlation
SWE1 PYC1 0.53862
SWE1 YBR204C 0.51554
SWE1 BOI2 0.50379
SWE1 LSM12 0.49418
SWE1 YIL158W 0.479
SWE1 SOL2 0.46634
SWE1 YOS9 0.46457
SWE1 BAR1 0.45635
SWE1 IOC4 0.43157
SWE1 YIL028W 0.42562

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YJL187C

Other databases:

Visit YJL187C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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