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YJL180C / ATP12



Section 1: Phenotypes.
Gene-drug relationships for YJL180C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL180C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ATP12 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 12.7204 0.0030617
thiabendazole 500 uM 8.81135 9.6872e-12
cantharidin 250 uM 8.36815 0.0069908
methotrexate 500 uM 8.07687 1.5948e-09
progesterone 250 uM 7.3936 1.0384e-09
cantharidin 250 uM 6.74465 0.010642
itraconazole 35.4 uM 5.04655 3.5929e-06
drofenine hydrochloride 750 uM 4.47945 2.3843e-05
clotrimazole 1 uM 4.33494 3.8193e-05
acriflavinium hydrochloride 250 uM 3.56865 0.00041958

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ATP12 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 21.5428 < 1e-12
psoralen 0.5 uM 8.07562 1.0714e-07
angelicin 62.5 uM 7.39621 3.6774e-07
bleomycin 1.7 ug/ml 4.62475 0.00010524
bleomycin 1.13 ug/ml 4.02625 0.00039607
bleomycin 1.13 ug/ml 3.92658 0.00049454
myriocin 0.2 ug/ml 3.80066 0.00065472
latrunculin 0.78 uM 3.44642 0.03743
mechlorethamine 62.5 uM 3.44616 0.037435
mms 0.002 % 3.31551 0.040091

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL180C

Top 10 functional gene interactors with YJL180C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ATP12 by heterozygous co-sensitivity:

Query Interactor Correlation
ATP12 SPT10 0.82425
ATP12 OST1 0.7886
ATP12 YML6 0.78576
ATP12 RMD9 0.76961
ATP12 MRPL49 0.76049
ATP12 YPR085C 0.75674
ATP12 DEM1 0.736
ATP12 NAB2 0.73388
ATP12 RDS3 0.72905
ATP12 FAD1 0.72796

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YJL180C

Other databases:

Visit YJL180C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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