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YJL169W / YJL169W



Section 1: Phenotypes.
Gene-drug relationships for YJL169W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL169W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YJL169W Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 21.2674 < 1e-12
doxorubicin 62.5 uM 11.8026 < 1e-12
wiskostatin 29 uM 7.31049 1.3033e-08
5-fluorocytosine 15.6 uM 6.35279 3.9278e-08
caspofungin 10 nM 6.15777 7.7632e-08
clozapine 500 uM 6.01185 1.2914e-07
caspofungin 10 nM 5.93015 1.7165e-07
methotrexate 250 uM 5.61357 5.1486e-07
methotrexate 250 uM 5.5063 7.4565e-07
itraconazole 4.4 uM 5.09982 2.9988e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YJL169W Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 62.5 uM 29.1153 0.00058879
licl 100 mM 25.7238 < 1e-12
mms 0.002 % 18.5802 0.0014421
mechlorethamine 62.5 uM 17.8413 0.0015634
mechlorethamine 62.5 uM 15.0682 0.0021877
wiskostatin 29 uM 11.5497 < 1e-12
licl 100 mM 11.4031 5.7114e-10
rapamycin 6 nM 10.9364 < 1e-12
mechlorethamine 62.5 uM 10.5384 0.0044422
latrunculin 0.78 uM 10.4546 0.0045127

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL169W

Top 10 functional gene interactors with YJL169W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YJL169W by heterozygous co-sensitivity:

Query Interactor Correlation
YJL169W SET2 0.36842
YJL169W RAD5 0.29676
YJL169W CEF1 0.29672
YJL169W CUP5 0.29105
YJL169W UFD2 0.28893
YJL169W SWR1 0.2886
YJL169W YPL205C 0.28579
YJL169W YOL138C 0.27175
YJL169W SPC2 0.27138
YJL169W VPS25 0.26783

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YJL169W by homozygous co-sensitivity:

Query Interactor Correlation
YJL169W SET2 0.77074
YJL169W RCO1 0.63206
YJL169W EAF3 0.62597
YJL169W YMR075C-A 0.59462
YJL169W BDF2 0.54091
YJL169W ARP6 0.49927
YJL169W CDC50 0.46914
YJL169W EAF7 0.46737
YJL169W SNC2 0.45311
YJL169W SWC5 0.45133

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YJL169W

Other databases:

Visit YJL169W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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