Retrieving results for YJL162C, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YJL162C / JJJ2



Section 1: Phenotypes.
Gene-drug relationships for YJL162C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL162C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for JJJ2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
telomerase inhibitor ix (Biomol) 500 uM 4.4343 5.0978e-05
sulconazole nitrate 0.24 uM 3.88866 0.00015783
hydroxyurea 50000 uM 3.69381 0.00028751
lapachol 500 uM 3.56211 0.00042787
itraconazole 4.4 uM 3.32548 0.00085925
mechlorethamine 250 uM 3.16304 0.0013677
hexestrol 125 uM 3.14694 0.0014313
lovastatin 154.5 uM 2.87208 0.0030499
trichlormethine 1000 uM 2.80157 0.0036809
clotrimazole 1 uM 2.79341 0.0037612

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for JJJ2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 38.1972 0.00034234
rapamycin 6 nM 20.6112 < 1e-12
mms 0.002 % 17.6951 0.0015892
latrunculin 0.78 uM 17.1979 0.001682
rapamycin 9 nM 16.2891 0.0018738
cadmium chloride 7.81 uM 10.9712 < 1e-12
wiskostatin 29 uM 10.8921 < 1e-12
rapamycin 4.88 nM 9.99412 5.9213e-12
synthetic complete for BY4743 0 7.63513 0.0083625
calyculin a 2.5 uM 7.14408 1.4684e-08

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL162C

Top 10 functional gene interactors with YJL162C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with JJJ2 by heterozygous co-sensitivity:

Query Interactor Correlation
JJJ2 HFA1 0.63682
JJJ2 YJL152W 0.62862
JJJ2 MSC6 0.5477
JJJ2 SPO74 0.54121
JJJ2 CRP1 0.54096
JJJ2 FKH2 0.53321
JJJ2 SMF1 0.53258
JJJ2 SOP4 0.51803
JJJ2 FMP45 0.51775
JJJ2 DIN7 0.51351

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with JJJ2 by homozygous co-sensitivity:

Query Interactor Correlation
JJJ2 YIL077C 0.71843
JJJ2 YIL158W 0.71274
JJJ2 GVP36 0.69803
JJJ2 BAR1 0.68812
JJJ2 SNL1 0.65865
JJJ2 YIL029C 0.64754
JJJ2 YIL028W 0.64205
JJJ2 FIS1 0.62456
JJJ2 SEC28 0.61669
JJJ2 PRK1 0.61575

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YJL162C

Other databases:

Visit YJL162C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.