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YJL140W / RPB4



Section 1: Phenotypes.
Gene-drug relationships for YJL140W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL140W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPB4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dyclonine 500 uM 11.7531 3.0471e-08
fenpropimorph 1.65 nM 9.92323 8.8691e-05
terbinafine 7.2 uM 9.39703 3.4913e-07
wiskostatin 29 uM 8.69288 3.1042e-10
aphidicolin glycinate 125 uM 8.26814 9.5457e-10
papuamide b 0.37 ug/ml 7.88883 2.6533e-09
distamycin a 250 uM 7.0163 2.9703e-08
no drug minimal media 0 6.74919 0.00054192
no drug minimal media 0 6.43224 0.00067468
no drug minimal media 0 6.28381 0.00074988

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPB4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 2.39073 0.013977
licl 100 mM 2.12477 0.023856
curcumin 150 uM 1.93309 0.034557
bleomycin 1.13 ug/ml 1.87426 0.03861
bleomycin 1.7 ug/ml 1.66845 0.056264
latrunculin 0.78 uM 1.40988 0.08781
mechlorethamine 62.5 uM 0.91683 0.18568
4nqo 0.0313 uM 0.912246 0.18685
licl 100 mM 0.853014 0.20243
benomyl 10 ug/ml 0.842775 0.20521

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL140W

Top 10 functional gene interactors with YJL140W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPB4 by heterozygous co-sensitivity:

Query Interactor Correlation
RPB4 RPB7 0.58578
RPB4 RPB3 0.56109
RPB4 RPB9 0.5216
RPB4 RPB11 0.50331
RPB4 RPB2 0.46131
RPB4 RPO26 0.45572
RPB4 SEC4 0.4381
RPB4 YDL211C 0.43017
RPB4 SPT20 0.40268
RPB4 SPT7 0.38335

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YJL140W

Other databases:

Visit YJL140W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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