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Yeast Fitness
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YJL138C / TIF2



Section 1: Phenotypes.
Gene-drug relationships for YJL138C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL138C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TIF2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dyclonine 500 uM 9.59221 2.8026e-07
itraconazole 4.4 uM 6.91332 5.5335e-09
fenpropimorph 4.7 uM 5.99006 1.3933e-07
methotrexate 250 uM 5.97239 1.4817e-07
methotrexate 250 uM 5.93523 1.6864e-07
mitomycin c 1000 uM 5.56122 6.1694e-07
methotrexate 500 uM 5.29902 4.1622e-06
lapachol 1000 uM 4.99489 4.2794e-06
methotrexate 250 uM 4.69838 1.157e-05
itraconazole 17.7 uM 4.31322 4.0977e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for TIF2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
minimal media 0 27.0912 5.4305e-11
synthetic complete for BY4743 0 22.3339 1.6717e-06
synthetic complete for BY4743 0 20.6259 2.4793e-06
synthetic complete for BY4743 0 16.4621 3.7229e-07
synthetic complete for BY4743 0 14.4642 1.425e-05
synthetic complete for BY4743 0 13.9694 1.1399e-06
synthetic complete for BY4743 0 13.8092 1.7879e-05
sodium sulfate 625 uM 11.4949 < 1e-12
minimal media 0 10.911 1.6738e-11
nocodazole 10 ug/ml 8.06311 1.0954e-07

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL138C

Top 10 functional gene interactors with YJL138C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TIF2 by heterozygous co-sensitivity:

Query Interactor Correlation
TIF2 BIO4 0.41851
TIF2 ARG5,6 0.38524
TIF2 AIR1 0.38456
TIF2 FUS1 0.36372
TIF2 GTR1 0.35278
TIF2 YIR014W 0.34785
TIF2 MSC2 0.34692
TIF2 HOS1 0.33804
TIF2 YCL049C 0.32813
TIF2 YIL054W 0.32369

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with TIF2 by homozygous co-sensitivity:

Query Interactor Correlation
TIF2 YMR144W 0.48137
TIF2 IMP1 0.45352
TIF2 MET1 0.44172
TIF2 RIF1 0.43963
TIF2 APC9 0.43578
TIF2 FPR1 0.42437
TIF2 STE50 0.42181
TIF2 YJL070C 0.41644
TIF2 YHI9 0.4122
TIF2 ROD1 0.40691

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YJL138C

Other databases:

Visit YJL138C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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