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YJL136C / RPS21B



Section 1: Phenotypes.
Gene-drug relationships for YJL136C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL136C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPS21B Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 428.492 2.7232e-06
drofenine hydrochloride 750 uM 10.7476 < 1e-12
clozapine 500 uM 9.07413 4.9686e-12
methotrexate 500 uM 8.52519 4.8235e-10
methotrexate 500 uM 8.48586 5.3516e-10
propiomazine maleate 500 uM 7.85246 2.1328e-10
amitriptyline hydrochloride 250 uM 6.56662 1.8596e-08
fenpropimorph 4.7 uM 4.95354 4.9207e-06
metergoline 250 uM 4.73417 1.027e-05
lapachol 500 uM 4.6708 1.2681e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPS21B Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 15.2865 4.6943e-12
bisphenol 125 uM 2.3092 0.016504
synthetic complete for BY4743 0 2.16093 0.059735
cantharidin analog 250 ug/ml 1.38642 0.087321
xanthohumol 6.2 uM 1.29 0.10288
l-dopa 12.5 ug/ml 1.09698 0.14018
l-dopa 12.5 ug/ml 0.986945 0.16532
5-fluorouracil 19.2 uM 0.97791 0.17092
norcantharidin 2500 uM 0.87542 0.19374
cantharidin analog 125 ug/ml 0.854718 0.19934

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL136C

Top 10 functional gene interactors with YJL136C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPS21B by heterozygous co-sensitivity:

Query Interactor Correlation
RPS21B RPS17A 0.72362
RPS21B RPS27B 0.66427
RPS21B YPR136C 0.6614
RPS21B RPS20 0.65752
RPS21B RPS3 0.65626
RPS21B BUB1 0.65036
RPS21B RRP9 0.63579
RPS21B RPS18A 0.63387
RPS21B RPS6A 0.62766
RPS21B FYV1 0.61904

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

Top 10 interactors with RPS21B by homozygous co-sensitivity:

Query Interactor Correlation
RPS21B RPS23A 0.50237
RPS21B RPS11B 0.49056
RPS21B RPS29B 0.48851
RPS21B YNL050C 0.46847
RPS21B SRV2 0.46771
RPS21B RSM24 0.456
RPS21B SSF1 0.45577
RPS21B RPS6B 0.45547
RPS21B RPL34A 0.45155
RPS21B ATP7 0.44638

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:




External information about YJL136C

Other databases:

Visit YJL136C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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