Retrieving results for YJL127C, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YJL127C / SPT10



Section 1: Phenotypes.
Gene-drug relationships for YJL127C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL127C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SPT10 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 500 uM 4.91774 5.5518e-06
fenbendazole 500 uM 3.39772 0.0006962
acriflavinium hydrochloride 250 uM 2.69589 0.0048554
miconazole 50 nM 2.56071 0.012484
latrunculin 6.25 uM 2.55883 0.010512
cantharidin 250 uM 2.53493 0.063355
latrunculin 2.8 uM 2.46989 0.0086011
licl 150 mM 2.34381 0.012731
dmso 4% 4 uM 2.30525 0.012807
cuso4 10000 uM 2.29609 0.014184

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SPT10 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
bleomycin 1.13 ug/ml 4.37705 0.00018173
bleomycin 1.13 ug/ml 3.82775 0.00061637
bleomycin 1.7 ug/ml 3.60097 0.0010214
angelicin 62.5 uM 3.40032 0.0015946
latrunculin 0.78 uM 3.22931 0.0023263
latrunculin 0.78 uM 3.09458 0.045238
rapamycin 9 nM 3.0335 0.046827
bleomycin 1.7 ug/ml 2.7651 0.0063773
mechlorethamine 62.5 uM 2.74756 0.055434
latrunculin 0.78 uM 2.33967 0.050626

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL127C

Top 10 functional gene interactors with YJL127C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SPT10 by heterozygous co-sensitivity:

Query Interactor Correlation
SPT10 OST1 0.86351
SPT10 YML6 0.85908
SPT10 RMD9 0.832
SPT10 MTF2 0.82577
SPT10 ATP12 0.82425
SPT10 MRPL49 0.81023
SPT10 YPR085C 0.80585
SPT10 NAB2 0.80166
SPT10 DEM1 0.80112
SPT10 URE2 0.79977

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YJL127C

Other databases:

Visit YJL127C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.