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YJL084C / ALY2



Section 1: Phenotypes.
Gene-drug relationships for YJL084C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL084C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ALY2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fenpropimorph 8 nM 6.28329 5.0079e-08
methotrexate 500 uM 5.26096 1.7315e-06
miconazole 100 uM 4.99363 4.2977e-06
lapachol 1000 uM 4.67293 1.2591e-05
atorvastatin 125 uM 4.53976 1.9558e-05
caspofungin 10 nM 4.3869 3.226e-05
doxorubicin 62.5 uM 4.15275 6.8644e-05
drofenine hydrochloride 750 uM 4.11585 7.721e-05
mechlorethamine 500 uM 4.10374 8.0243e-05
caspofungin 10 nM 3.7105 0.00027325

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ALY2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 21.6639 < 1e-12
fk506 0.1 ug/ml 7.85651 1.8992e-09
fk506 0.05 ug/ml 5.90604 5.7024e-07
synthetic complete for BY4743 0 5.85987 0.013954
synthetic complete for BY4743 0 5.45796 0.0060424
methotrexate 500 uM 5.4294 1.8504e-05
zncl2 1875 uM 4.99117 8.8181e-06
myriocin 0.2 ug/ml 4.68438 9.2332e-05
hydroxyurea 50000 uM 4.54176 3.3459e-05
rapamycin 6 nM 4.44775 4.4117e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL084C

Top 10 functional gene interactors with YJL084C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ALY2 by heterozygous co-sensitivity:

Query Interactor Correlation
ALY2 YKL030W 0.48923
ALY2 YPR096C 0.48174
ALY2 YKU70 0.4735
ALY2 ZSP1 0.47155
ALY2 YNL105W 0.45304
ALY2 YMR135W-A 0.44052
ALY2 YPL230W 0.43801
ALY2 YPL236C 0.4327
ALY2 ERV41 0.42345
ALY2 ARN2 0.42343

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ALY2 by homozygous co-sensitivity:

Query Interactor Correlation
ALY2 ASI2 0.68073
ALY2 YLR255C 0.61921
ALY2 MNI2 0.61522
ALY2 PAN3 0.60585
ALY2 SMY2 0.59457
ALY2 LYS20 0.5804
ALY2 STP2 0.57979
ALY2 YMR119W-A 0.57836
ALY2 ZEO1 0.57521
ALY2 YPR114W 0.57184

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YJL084C

Other databases:

Visit YJL084C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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