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Yeast Fitness
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YJL058C / BIT61



Section 1: Phenotypes.
Gene-drug relationships for YJL058C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL058C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BIT61 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 7.53937 0.0085708
drofenine hydrochloride 750 uM 5.04449 3.618e-06
methotrexate 125 uM 3.94537 0.00013224
caspofungin 10 nM 3.87282 0.0001658
caspofungin 10 nM 3.3269 0.00085571
lovastatin 154.5 uM 3.1725 0.0013316
clotrimazole 1 uM 3.11184 0.0015797
cloxyquin 15.6 uM 2.94192 0.0025254
methotrexate 250 uM 2.89317 0.0028817
metergoline 250 uM 2.86555 0.0031038

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BIT61 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 5.91312 0.013714
methotrexate 500 uM 3.89629 0.00052906
rapamycin 6 nM 3.07379 0.0020739
mechlorethamine 62.5 uM 2.94167 0.049371
hydroxyurea 100000 uM 2.84959 0.0053206
sodium sulfate 625 uM 2.80837 0.0040957
myriocin 0.2 ug/ml 2.70656 0.0072245
synthetic complete for BY4743 0 2.68263 0.01571
psoralen 0.5 uM 2.57884 0.009461
hgcl2 62.5 uM 2.44267 0.0099644

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL058C

Top 10 functional gene interactors with YJL058C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BIT61 by heterozygous co-sensitivity:

Query Interactor Correlation
BIT61 XPT1 0.51669
BIT61 YNR063W 0.49225
BIT61 ATG10 0.48476
BIT61 COS1 0.47792
BIT61 ADE17 0.47366
BIT61 YJL068C 0.4714
BIT61 ITT1 0.46733
BIT61 SUT2 0.4617
BIT61 MNT3 0.46075
BIT61 RPL1A 0.45722

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with BIT61 by homozygous co-sensitivity:

Query Interactor Correlation
BIT61 YUH1 0.74431
BIT61 SSA1 0.73524
BIT61 YJR098C 0.72623
BIT61 GAS2 0.71017
BIT61 DLD2 0.6966
BIT61 YNL011C 0.6938
BIT61 MAL12 0.66451
BIT61 ITT1 0.66149
BIT61 LEU1 0.66086
BIT61 SAM2 0.65557

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YJL058C

Other databases:

Visit YJL058C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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