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Yeast Fitness
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YJL031C / BET4



Section 1: Phenotypes.
Gene-drug relationships for YJL031C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL031C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BET4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 15.7296 1.8702e-11
miconazole 25 nM 10.6408 < 1e-12
5-fluorocytosine 15.6 uM 3.73139 0.00025637
methotrexate 500 uM 3.56643 0.00058152
solasodine 250 uM 3.10407 0.0016144
no drug minimal media 0 2.92495 0.016412
5-fluorocytosine 15.6 uM 2.83709 0.0033493
5-fluorocytosine 15.6 uM 2.7343 0.0043935
methotrexate 250 uM 2.6538 0.0054126
thiabendazole 250 uM 2.60738 0.0060946

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YJL031C

Top 10 functional gene interactors with YJL031C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BET4 by heterozygous co-sensitivity:

Query Interactor Correlation
BET4 MTG1 0.72054
BET4 CAF17 0.71078
BET4 YMR293C 0.70974
BET4 RNA1 0.70659
BET4 MRP51 0.68722
BET4 YAR1 0.68596
BET4 PGA1 0.68431
BET4 MDM12 0.68341
BET4 YJL032W 0.68083
BET4 MRPL49 0.67272

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YJL031C

Other databases:

Visit YJL031C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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