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YJL029C / VPS53

Section 1: Phenotypes.
Gene-drug relationships for YJL029C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL029C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for VPS53 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 18.4085 < 1e-12
alverine citrate 500 uM 17.673 2.9404e-10
nocodazole 2 ug/ml 17.1801 < 1e-12
ketoconazole 11.8 uM 11.8677 1.2078e-09
5-fluorocytosine 15.6 uM 6.75289 9.694e-09
bithionol 75 uM 6.04313 1.158e-07
bithionol 75 uM 5.97612 1.4626e-07
bithionol 75 uM 5.40425 1.0595e-06
fluconazole 65.3 uM 4.66158 1.3075e-05
caspofungin 10 nM 4.4571 2.5654e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

Top 10 sensitivity-inducing conditions for VPS53 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 100 mM 7.69624 2.1171e-07
potassium disulfite 2500 uM 7.37763 3.8069e-07
bleomycin 1.7 ug/ml 7.31058 4.3147e-07
licl 100 mM 7.30058 4.3962e-07
bleomycin 1.13 ug/ml 6.69784 1.3937e-06
bleomycin 1.7 ug/ml 6.57183 1.7849e-06
ph4 7.5 6.45985 2.228e-06
latrunculin 0.78 uM 6.43151 2.3572e-06
bleomycin 1.13 ug/ml 6.35098 2.7683e-06
papuamide b 0.7 ug/ml 6.2593 3.3279e-06

More... (click to see all Homozygous data)

Section 2: Co-fitness interactions.
Gene-gene relationships for YJL029C

Top 10 functional gene interactors with YJL029C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with VPS53 by heterozygous co-sensitivity:

Query Interactor Correlation
VPS53 ASF1 0.62538
VPS53 CPR7 0.597
VPS53 YMR293C 0.58373
VPS53 ESS1 0.57435
VPS53 TOM5 0.57342
VPS53 NAF1 0.56803
VPS53 YFH1 0.55946
VPS53 MRPL51 0.55922
VPS53 YNL171C 0.55374
VPS53 MTG1 0.55244

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YJL029C

Other databases:

Visit YJL029C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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