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YJL020C / BBC1



Section 1: Phenotypes.
Gene-drug relationships for YJL020C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YJL020C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BBC1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 17.9581 2.4424e-10
papuamide b 0.125 ug/ml 11.5929 < 1e-12
miconazole 0.2 uM 11.4311 2.0724e-09
ketoconazole 11.8 uM 9.98661 1.3993e-08
latrunculin 3.91 uM 9.86313 1.5864e-11
latrunculin 1.95 uM 8.44547 5.9554e-10
nocodazole 2 ug/ml 8.42628 3.1276e-11
amphotericin b 10 uM 7.82109 2.3745e-10
myriocin 0.15 ug/ml 6.86364 4.5702e-08
clozapine 500 uM 6.43305 2.9668e-08

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BBC1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 97.2968 5.2809e-05
latrunculin 0.78 uM 63.7107 0.00012314
latrunculin 0.78 uM 59.0446 5.3512e-06
latrunculin 0.975 uM 36.2954 < 1e-12
latrunculin 0.78 uM 32.9348 < 1e-12
latrunculin 3 uM 29.1144 < 1e-12
latrunculin 0.78 uM 25.2497 < 1e-12
37 degrees C 0 15.6585 < 1e-12
mncl2 2 mM 13.9184 < 1e-12
nystatin 10 uM 11.3178 2.5278e-07

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YJL020C

Top 10 functional gene interactors with YJL020C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BBC1 by heterozygous co-sensitivity:

Query Interactor Correlation
BBC1 YIL059C 0.59907
BBC1 KTR7 0.58417
BBC1 RPS24B 0.5687
BBC1 CBR1 0.54168
BBC1 MMF1 0.52831
BBC1 SDS3 0.50516
BBC1 YIL012W 0.50086
BBC1 MUP3 0.49301
BBC1 FAF1 0.49059
BBC1 STV1 0.47309

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with BBC1 by homozygous co-sensitivity:

Query Interactor Correlation
BBC1 BBC1_p 0.74097
BBC1 YIR003W 0.64734
BBC1 YFR016C 0.56911
BBC1 PFA4 0.50344
BBC1 YOL048C 0.48358
BBC1 PEA2 0.48096
BBC1 MSO1 0.47511
BBC1 CUP9 0.47157
BBC1 PAA1 0.46041
BBC1 YKL162C 0.46038

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YJL020C

Other databases:

Visit YJL020C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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