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Yeast Fitness

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YIR022W / SEC11

Section 1: Phenotypes.
Gene-drug relationships for YIR022W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YIR022W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SEC11 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 8.34188 1.6044e-07
alverine citrate 500 uM 8.26128 0.007169
alverine citrate 500 uM 7.48741 0.0086871
doxorubicin 62.5 uM 3.66145 0.0003172
tunicamycin 0.15 uM 3.55038 0.0013322
acriflavinium hydrochloride 250 uM 3.49192 0.00052743
miconazole 100 uM 3.38648 0.00071948
miconazole 100 uM 3.04532 0.0019013
juglone 200 uM 2.73041 0.0050999
caspofungin 10 nM 2.6878 0.0049582

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YIR022W

Top 10 functional gene interactors with YIR022W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with SEC11 by heterozygous co-sensitivity:

Query Interactor Correlation
SEC11 CET1 0.42719
SEC11 AGP2 0.4263
SEC11 SPT20 0.40305
SEC11 CRD1 0.38585
SEC11 ATG1 0.35675
SEC11 FAS2 0.35611
SEC11 TIM22 0.34909
SEC11 PRT1 0.3482
SEC11 KAR2 0.34446
SEC11 YBR012C 0.34077

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YIR022W

Other databases:

Visit YIR022W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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