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Yeast Fitness

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YIR008C / PRI1

Section 1: Phenotypes.
Gene-drug relationships for YIR008C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YIR008C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PRI1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 6.817 2.0694e-06
wiskostatin 29 uM 6.34966 1.9798e-07
methotrexate 500 uM 6.17941 3.2319e-07
metergoline 250 uM 6.03921 1.174e-07
fluconazole 65.3 uM 5.90697 1.8606e-07
ketoconazole 11.8 uM 5.75854 1.4674e-05
thiabendazole 250 uM 5.60368 5.3277e-07
4-isopropyltropolone 15.63 uM 4.61309 3.0478e-05
tunicamycin 0.15 uM 4.61211 0.0028883
ID 693632 62.5 uM 4.47836 4.4922e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YIR008C

Top 10 functional gene interactors with YIR008C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with PRI1 by heterozygous co-sensitivity:

Query Interactor Correlation
PRI1 FAF1 0.44905
PRI1 URM1 0.41645
PRI1 GPI14 0.37887
PRI1 NOP9 0.37829
PRI1 YIR007W 0.37641
PRI1 SNP1 0.36704
PRI1 APM2 0.36325
PRI1 SDL1 0.36214
PRI1 VID28 0.35471
PRI1 YIL171W 0.35348

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YIR008C

Other databases:

Visit YIR008C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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