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Yeast Fitness
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YIL159W / BNR1



Section 1: Phenotypes.
Gene-drug relationships for YIL159W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YIL159W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BNR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 10.4629 3.7031e-12
latrunculin 1.95 uM 5.14678 6.4835e-06
miconazole 0.2 uM 4.84916 8.8814e-05
fenpropimorph 1.2 uM 4.35761 3.5484e-05
acriflavinium hydrochloride 250 uM 4.18426 6.2065e-05
methotrexate 500 uM 4.01134 0.00016962
itraconazole 4.4 uM 3.60218 0.00037939
cantharidin disodium 100 uM 3.53435 0.00063449
cloxyquin 15.6 uM 2.86429 0.0031144
bithionol 75 uM 2.77776 0.0039199

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BNR1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 24.7849 0.00081197
latrunculin 0.78 uM 16.7206 0.0017789
latrunculin 0.975 uM 15.0288 < 1e-12
latrunculin 0.78 uM 14.794 0.00033503
mms 0.002 % 11.7774 0.0035662
cadmium chloride 7.81 uM 9.96066 6.4517e-12
nocodazole 10 ug/ml 9.48427 1.0023e-08
latrunculin 0.78 uM 8.91548 2.5337e-08
latrunculin 3 uM 8.84231 2.8628e-08
mncl2 2 mM 8.01181 1.2251e-09

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YIL159W

Top 10 functional gene interactors with YIL159W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BNR1 by heterozygous co-sensitivity:

Query Interactor Correlation
BNR1 BCP1 0.36715
BNR1 BRN1 0.36331
BNR1 ATP22 0.35493
BNR1 SNM1 0.33016
BNR1 YDR128W 0.32969
BNR1 UBC12 0.31671
BNR1 CAP2 0.31354
BNR1 YJR088C 0.30659
BNR1 YOL022C 0.29626
BNR1 YGR125W 0.29421

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with BNR1 by homozygous co-sensitivity:

Query Interactor Correlation
BNR1 YMR244W 0.5418
BNR1 HES1 0.5393
BNR1 HMS2 0.5332
BNR1 SIM1 0.53014
BNR1 MDH2 0.50923
BNR1 YJL016W_p 0.50854
BNR1 LSB6 0.50138
BNR1 AYR1 0.49385
BNR1 YBR139W 0.49142
BNR1 PRM8 0.48964

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YIL159W

Other databases:

Visit YIL159W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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