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Yeast Fitness
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YIL146C / ECM37



Section 1: Phenotypes.
Gene-drug relationships for YIL146C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YIL146C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ECM37 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 6.33818 2.0462e-07
cloxyquin 15.6 uM 3.40125 0.00068904
cantharidin 100 uM 3.29064 0.0012195
lovastatin 62.5 uM 3.27602 0.0009911
caspofungin 10 nM 3.24059 0.0010971
fenpropimorph 2.3 uM 2.98413 0.0022505
itraconazole 17.7 uM 2.96498 0.0023715
itraconazole 17.7 uM 2.94221 0.0025234
paraquat 2000 uM 2.86085 0.0036922
metergoline 250 uM 2.78181 0.0038783

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ECM37 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 40.0771 < 1e-12
rapamycin 6 nM 34.8425 < 1e-12
cadmium chloride 7.81 uM 20.2822 < 1e-12
mncl2 2 mM 11.4322 < 1e-12
rapamycin 4.88 nM 10.8215 < 1e-12
mms 0.002 % 8.16559 0.0073343
mpp+ 250 ug/ml 6.2351 2.1359e-07
calyculin a 2.5 uM 5.89605 5.8754e-07
methotrexate 250 uM 5.19107 1.0155e-05
mncl2 1 mM 5.04163 7.5853e-06

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YIL146C

Top 10 functional gene interactors with YIL146C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ECM37 by heterozygous co-sensitivity:

Query Interactor Correlation
ECM37 YMR210W 0.43564
ECM37 YAL027W 0.42076
ECM37 TEL1 0.41951
ECM37 IZH1 0.4133
ECM37 YOL046C 0.41194
ECM37 GZF3 0.41003
ECM37 YLR400W 0.40886
ECM37 BAP3 0.406
ECM37 PCI8 0.40533
ECM37 YHL039W 0.40237

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ECM37 by homozygous co-sensitivity:

Query Interactor Correlation
ECM37 KIP2 0.732
ECM37 YIL092W 0.7207
ECM37 BAR1 0.71638
ECM37 IZH1 0.71463
ECM37 YJL215C 0.6585
ECM37 ASP1 0.65246
ECM37 IZH3 0.64903
ECM37 YGL160W 0.63874
ECM37 PSR1 0.63761
ECM37 YPR091C 0.63215

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YIL146C

Other databases:

Visit YIL146C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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