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Yeast Fitness
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YIL136W / OM45



Section 1: Phenotypes.
Gene-drug relationships for YIL136W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YIL136W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for OM45 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
metergoline 250 uM 8.93705 6.9121e-12
cantharidin 250 uM 7.89721 0.0078294
methotrexate 500 uM 7.75259 3.8469e-09
thiabendazole 250 uM 7.59195 5.2246e-10
lovastatin 77.2 uM 7.39948 1.0174e-09
drofenine hydrochloride 750 uM 7.00965 3.953e-09
mitomycin c 1000 uM 6.65672 1.3569e-08
lapachol 1000 uM 6.35656 3.8765e-08
clozapine 500 uM 5.92333 1.7577e-07
amphotericin b 10 uM 5.69957 3.8231e-07

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for OM45 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 6.9859 0.00046265
licl 100 mM 6.62207 1.6169e-06
synthetic complete for BY4743 0 5.38884 0.0014845
synthetic complete for BY4743 0 4.80261 0.0085913
synthetic complete for BY4743 0 4.08371 0.00034851
l-dopa 12.5 ug/ml 4.08166 0.00012804
nocodazole 10 ug/ml 3.65051 0.00091478
mechlorethamine 62.5 uM 3.06495 0.0033356
mncl2 2 mM 2.94436 0.0028999
nocodazole 10 ug/ml 2.86476 0.0051496

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YIL136W

Top 10 functional gene interactors with YIL136W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with OM45 by heterozygous co-sensitivity:

Query Interactor Correlation
OM45 APL1 0.432
OM45 NOP9 0.41073
OM45 MMF1 0.40201
OM45 GPI14 0.366
OM45 SDL1 0.36356
OM45 PIG2 0.36318
OM45 CBR1 0.36207
OM45 TMA108 0.35693
OM45 SDP1 0.35193
OM45 CAP2 0.34608

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with OM45 by homozygous co-sensitivity:

Query Interactor Correlation
OM45 YGR201C 0.73009
OM45 DAK1 0.68542
OM45 DMA1 0.68028
OM45 YPL162C 0.67919
OM45 GAD1 0.67133
OM45 KIN2 0.66313
OM45 PUT2 0.65721
OM45 UIP4 0.65281
OM45 SOL2 0.64961
OM45 YMR244C-A 0.63806

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YIL136W

Other databases:

Visit YIL136W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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